Nanoparticle formulated alpha-galactosylceramide activates NKT cells without inducing anergy
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چکیده
منابع مشابه
Liver Injury After Invariant NKT Cell Activation by Free Alpha-galactosylceramide and Alpha-galactosylceramide-loaded Dendritic Cells.
BACKGROUND/AIM Both free alpha-galactosylceramide (αGalCer) and αGalCer-loaded dendritic cells (DCG) activate invariant natural killer T (iNKT) cells to varying degrees, with αGalCer inducing liver injury. We sought to evaluate liver injury by these two pathways. MATERIALS AND METHODS Mice were injected with αGalCer or DCG followed by analysis of serum alanine transaminase (ALT) activity leve...
متن کاملβ-mannosylceramide activates type I natural killer t cells to induce tumor immunity without inducing long-term functional anergy.
PURPOSE Most studies characterizing antitumor properties of invariant natural killer T (iNKT) cells have used the agonist, α-galactosylceramide (α-GalCer). However, α-GalCer induces strong, long-lasting anergy of iNKT cells, which could be a major detriment for clinical therapy. A novel iNKT cell agonist, β-mannosylceramide (β-ManCer), induces strong antitumor immunity through a mechanism disti...
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NKT cells play a role in immunological regulation of certain diseases, and their frequency and/or function may be related to disease prognosis. However, it is often difficult to evaluate NKT cell function in patients with malignancies due to reduced numbers of NKT cells as well as the dysfunction of the APCs used as stimulators. We found that NKT cell function could not be evaluated by conventi...
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Because of the paucity of known self lipid-reactive ligands for NKT cells, interactions among distinct NKT cell subsets as well as immune consequences following recognition of self glycolipids have not previously been investigated. Here we examined cellular interactions and subsequent immune regulatory mechanism following recognition of sulfatide, a self-glycolipid ligand for a subset of CD1d-r...
متن کاملMechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1.
Repeated injection of alpha-galactosylceramide, an agonistic ligand for natural killer T (NKT) cells, results in long-term unresponsiveness or anergy, which severely limits its clinical application. However, the molecular mechanisms leading to NKT anergy induction remain unclear. We show here that the decreased IFN-gamma production and failed tumor rejection observed in anergized NKT cells are ...
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ژورنال
عنوان ژورنال: Vaccine
سال: 2009
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2009.01.047